In recent years, Korean cosmetic treatments have gained increasing popularity in Taiwan, with “hyaluronic acid injections” being particularly popular among beauty enthusiasts. As technology continues to advance, the market has evolved from initial hyaluronic acid-based treatments to third-generation skin rejuvenation injections that focus on “biological repair.” Today, we will compare three of the most discussed options: RE20 (Elravie Re2O), CellREDM, and the time-tested Rejuran, to help you make an informed decision before visiting a clinic. For convenience, this article refers to RE20 as RE20; its actual name is RE2o.
This article will introduce RE20 vs CellREDM vs Rejuran in the following sections.
- What are hyaluronic acid injections? A quick overview of the three main products.
- Detailed introduction to RE20 (Elravie Re2O)
- Detailed introduction to CellREDM
- Detailed introduction to Rejuran
- RE20 vs CellREDM vs Rejuran: A comprehensive comparison table
- A guide for choosing based on your skin type and concerns
- Treatment process, recovery time, and side effects
- Frequently asked questions
- Conclusion
I. What are Hyaluronic Acid injections? A quick overview of their three main categories
The term “hyaluronic acid injections” is well-known in Taiwan, but in fact this name encompasses a variety of different injection formulas and mechanisms of action. Simply put, the skin-enhancing injections currently available on the market can be divided into two main categories:
- PN (Polynucleotides) category: Represented by Rejuran, these products indirectly induce collagen production by stimulating the body’s own fibroblast cells.
- ECM (Extracellular Matrix) category: Represented by RE20 and CellREDM, these products directly replenish the structural components such as collagen, elastin, and glycosaminoglycans that are lost in the dermis.
These two approaches differ in their mechanisms and are suitable for different skin conditions. Next, we will introduce these three products in more detail.
Below are the price ranges for these three products according to the BeautsGO platform
| Product | Rejuran | RE20 | CellREDM |
|---|---|---|---|
| Price Range | ₩200k – ₩500k | ₩600k – ₩800k | ₩400k – ₩700k |
| Covered by BeautsGO | ✅Complete | ❌Very few | ❌Almost none |
| Common hospitals | imageup / jd / ogana | Mine / Advanced Dermatology | Alternative Clinics |
| Product Types | PN Repair | ECM Structure Reconstruction | ECM/ECM-like |
| Positioning | Repair-oriented Entry/Mid-range | Advanced Anti-aging | Mid-to-high-end alternatives |
II. Detailed introduction to RE20 (Elravie Re2O)
What is RE20?
RE20, officially named Elravie Re2O, was developed by the Korean company L&C Bio. It is the world’s first clinically approved hADM (Human Acellular Dermal Matrix) hyaluronic acid injection. It can be considered the “pioneer” in the field of ECM hyaluronic acid injections and is widely used in plastic and cosmetic clinics in the Gangnam area of Seoul, South Korea.
Composition and mechanism of action of RE20
The core component of RE20 is collagen ECM derived from human skin. This material undergoes a precise cell-decellularization process, removing cellular components that may trigger immune reactions (such as cells and fat) while retaining only the pure extracellular matrix structure. Its composition closely resembles the natural dermal structure of the human body. The main active ingredients include:
- Collagen: Provides structural support for the skin and enhances firmness
- Elastin: Restores the skin’s elasticity and tensile strength
- Hyaluronic Acid: Provides deep hydration and maintains the water content of the dermis
This “direct supplementation” mechanism is different from the superficial hydration provided by traditional hyaluronic acid injections. RE20 actually delivers these essential components directly into the dermis, allowing the skin to rebuild its structure from within.
The clinical effects of RE20
According to clinical data, the benefits brought by the RE20 treatment are quite diverse:
- Pores shrink by 26.9%
- Fine lines and wrinkles are significantly improved
- Irregularities and dullness of the skin are reduced
- Skin elasticity and firmness are enhanced
- Deep hydration is improved, and the skin’s barrier function is strengthened
It is particularly noteworthy that the effects of RE20 last for a relatively long time; the benefits from a single treatment can last for more than 6 months, especially in terms of reducing enlarged pores and restoring skin elasticity.
Particle size: 100 micrometers
RE20’s hADM particles have a size of approximately 100 micrometers, which is in line with industry standards. There is a slight resistance during application, but overall, the treatment is well-tolerated.
For a complete introduction to RE2o, please visit https://beautsgo.cceeo.com/blog/elravie-re2o/
III. Detailed Introduction to CellREDM
What is CellREDM?
CellREDM is manufactured by the Korean company Hans Biome and, like RE20, belongs to the hADM-derived ECM hyaluronic acid injections category. While its core concepts are very similar to those of RE20, CellREDM has been further optimized and upgraded in terms of its formula and administration experience. Currently, CellREDM is considered a “strong competitor” to RE20 at top clinics in Seoul’s Gangnam district; some doctors even refer to it as “the next generation of ECM hyaluronic acid injections.”
Ingredients and Features of CellREDM
Like RE20, CellREDM also uses human dermal matrix derived from adipose tissue. Its main ingredients include:
- Collagen: Supports the structural proteins of the dermis and enhances skin density.
- Elastin: Improves the skin’s elasticity and firmness.
- Glycosaminoglycans (GAGs): Enhance the dermis’ water-retaining capacity and improve skin texture.
Hans Biome possesses over 20 years of expertise in human tissue processing technology. It was the first organization in South Korea to be approved by the MFDS and holds dual certifications from the AATB and the US FDA, ensuring its high credibility in terms of raw material safety and quality control.
The biggest highlight of CellREDM: ultra-fine 75-micron particles
Compared to RE20’s 100-micron particles, CellREDM uses finer 75-micron particles, and this difference brings several significant advantages:
- Less resistance during injection: The smaller particles reduce the resistance encountered when injected into the dermis, making the process smoother.
- More even distribution: These fine particles can be more evenly distributed across various layers of the dermis, resulting in a better covering effect.
- Less discomfort: The overall experience during injection is less uncomfortable, making it particularly suitable for those who are sensitive to pain.
- Less post-injection swelling: The finer particles cause less immediate disturbance to the tissue, leading to faster recovery from any redness or bumps after the procedure.
In terms of its main benefits, CellREDM focuses on improving skin texture and increasing skin density, providing a noticeable “tightening effect from within” after use.
IV. Detailed Introduction to Rejuran
What is Rejuran?
Rejuran, also known as PDRN hyaluronic acid injection or PN hyaluronic acid injection, was developed by the Korean company Pharmaresearch. It is currently one of the most well-known skin-enhancing injections worldwide and enjoys high brand recognition in the Taiwanese and Southeast Asian markets.
Composition and Mechanism of Action of Rejuran
The core component of Rejuran is a polynucleotide extracted from salmon DNA. This DNA fragment is highly compatible with the human body and is purified before being injected into the dermis. Its mechanism of action is fundamentally different from that of ECM-based products:
- Rejuran does not directly supplement collagen; instead, it activates fibroblasts through the polynucleotide, indirectly inducing the production of natural collagen.
- It enhances the skin’s balance of moisture and oil, improving skin instability caused by excessive sebum production or dryness.
- It provides deep hydration, increasing the skin’s water content at the cellular level.
Key Effects of Rejuran
- It reduces fine lines and improves the overall texture of the skin.
- It restores the skin’s moisture and oil balance.
- It lightens mild acne scars and uneven skin tone.
- It promotes overall skin repair and enhances the skin’s ability to renew itself.
Rejuran Lijulandan Product BeautsGO Quote Sheet
| Product | Hospital | Specification | Price (Korean Won) |
|---|---|---|---|
| Rejuran Red Box | imageup clinic | 2cc | ₩500,000 |
| Rejuran White Box | imageup clinic | 1cc | ₩300,000 |
| Rejuran Black Box | imageup clinic | 2cc | ₩350,000 |
| Rejuran Red Box (HB) | jd clinic | 1cc | ₩200,000 |
| Rejuran White Box | jd clinic | 1cc | ₩200,000 |
| Rejuran Black Box | jd clinic | 2cc | ₩350,000 |
| Rejuran (model not specified) | Maylin Hospital | 1cc | ₩500,000 |
| Rejuran HB | Oganacell Dermatology Clinic | 1cc | ₩429,000 |
Features and Limitations of Rejuran
Rejuran is a relatively viscous injectable, and patients usually experience a noticeable swelling and pain during administration. The time it takes for the papules at the injection site to subside is also slightly longer compared to ECM-based products. Additionally, the effects of Rejuran are gradual and cumulative; it generally takes 2 to 4 weeks to see significant changes, which is different from the more immediate improvements in texture observed after treatments with RE20 or CellREDM.
V. RE20 vs CellREDM vs Rejuran: Comprehensive Comparison Table
比較項目 RE20（Elravie Re2O） CellREDM Rejuran 製造廠商 L&C Bio（韓國） Hans Biome（韓國） Pharmaresearch（韓國） 主要成分 hADM（人源 ECM） hADM（人源 ECM） PN 多核苷酸（鮭魚 DNA） 成分類別 ECM 細胞外基質 ECM 細胞外基質 PN 多核苷酸 作用機轉 直接補充真皮 ECM 直接補充真皮 ECM 激活纖維母細胞誘導膠原 顆粒大小 100 μm 75 μm（更細緻） N/A（溶液型） 疼痛感 中等 較低 較高 見效速度 術後即有質地改善 術後即有質地改善 2～4 週漸進顯效 術後腫脹 中等 較輕 較明顯，丘疹期較長 效果重點 毛孔縮小、彈力線恢復 膚質改善、皮膚密度 水油平衡、整體修復 效果持續 6 個月以上 6 個月以上 約 3～6 個月 最適膚況 毛孔粗大、皮膚鬆弛 膚質粗糙、密度不足 缺水膚質、整體修復
VI. Guidance on Choosing Based on Skin Type Issues
Situations Where RE20 Is the Right Choice
If you are experiencing any of the following issues, RE20 may be your top priority:
- Significantly coarser pores: RE20 has the strongest clinical data supporting its pore-minimizing effects
- Notable decrease in skin elasticity, feeling that the skin cannot be “lifted”
- Desiring to quickly see improvements in texture and lasting results
- Those familiar with ECM-based treatments or clinics with extensive experience administering RE20
Situations Where CellREDM Is the Right Choice
CellREDM should be considered in the following situations:
- Those who are more sensitive to pain and prefer a more comfortable treatment process
- For rough skin with low density, seeking an “inner-tightening” effect
- Desiring even distribution across the entire face for more refined ECM coverage
- Wishing for a quick recovery period after treatment to minimize disruption to daily life
Reasons for choosing Rejuran
Rejuran is particularly suitable for:
- Those with severely dehydrated skin and extreme imbalance in oil and moisture (dry or combination skin types)
- Those with mild acne scars or uneven skin tone, aiming for gradual overall skin improvement
- Younger individuals who prefer preventive maintenance rather than structural repair
- Those who have previously undergone ECM treatments and wish to alternate with different techniques
Doctors remind: Regardless of the treatment chosen, the most critical factor lies not in the product itself but in the skills and experience of the injector. Precise injection depth, even distribution, and personalized adjustments based on individual skin conditions are the key determinants of effectiveness. Be sure to seek consultation at a reputable medical aesthetics clinic and avoid opting for unqualified practitioners to save costs.
VII. Treatment Process, Recovery Period, and Side Effects
Treatment Procedure
- Pre-treatment Consultation: The doctor evaluates the skin condition and discusses the expected results and suitable products.
- Cleaning and Photography: Remove makeup and excess oil from the face, and take pre-treatment photographs.
- Anesthetic Application: Typically, a wait of 30–45 minutes is required to reduce discomfort during the injection.
- Injection Procedure: Depending on the product and the area being treated, the procedure takes approximately 20–40 minutes.
- Post-treatment Care: Apply ice packs, and use healing masks or serums at the injection sites.
Post-treatment Recovery and Side Effect Comparison
症狀 RE20 / CellREDM Rejuran 注射點丘疹 1～3 天內消退 可能持續 3～7 天 輕微泛紅 24 小時內 24～48 小時 腫脹感 輕微至中等 中等 瘀青（個人體質） 偶發 偶發
Post-treatment Precautions: Avoid strenuous exercise, steam baths, saunas, and alcohol for 48 hours after the treatment; do not press on the injection sites with your hands; protect your skin from sunlight to prevent pigmentation.
VIII. Frequently Asked Questions
Q1: Can RE20, CellREDM, and Rejuran be used together? A: Some clinics may design combined treatments
based on the patient’s skin condition, for example, using ECM injections (RE20 or CellREDM) as a base, followed by Rejuran for enhanced moisturizing and repair. The specific combination should be determined by a doctor; it is not recommended to request such combinations on your own.
Q2: How many treatments are needed to see results? A: It i
s generally recommended to complete 3 initial treatment sessions (with 4–6 weeks between each) before transitioning to maintenance treatments every 3–6 months. A single treatment can also be effective, but the effects will not last as long as a full course of treatment.
Q3: At what age is it appropriate to start using
these treatments? A: RE20 and CellREDM are suitable for people over 25 years old who are experiencing early signs of skin aging, such as enlarged pores and decreased elasticity. Rejuran, being more focused on moisturizing and repair, can be considered for those over 20 years old, depending on their skin condition.
Q4: Can they be used during pregnancy or while breastfeeding? A
: It is advised to avoid any injectable cosmetic treatments during pregnancy and breastfeeding. If you have any concerns, please consult a gynecologist and dermatologist first.
Q5: Where in Taiwan can these treatments be received
? A: Currently, RE20 and Rejuran are more commonly available at cosmetic clinics in Taiwan. CellREDM is mainly offered at clinics in the Gangnam area of Seoul, South Korea; some Taiwanese doctors also provide this service. It is best to inquire directly with the clinic whether they offer it. You can visit BeautsGO for specific prices and information on Korean dermatologists who perform these treatments.
Q6: What are the approximate cost
s? A: In South Korea, the cost of these treatments varies depending on the clinic; RE20 and CellREDM typically cost around 30,000–80,000 South Korean won per session. In Taiwan, due to import costs and varying clinic pricing, it is recommended to ask the clinic for the latest quotes.
IX. Conclusion
In summary, RE20, CellREDM, and Rejuran each have unique mechanisms of action and are suitable for different groups of people. There is no “best” option; rather, the one that “fits your current skin condition best” is the right choice.
- If you are concerned about issues such as pores, elasticity, and structural aging, RE20 or CellREDM from ECM are more direct and effective options.
- Among them, CellREDM’s finer particles offer slightly greater comfort; however, RE20 has a longer clinical history and more extensive data available.
- If your main concerns are dry skin, uneven skin tone, or overall skin repair, Rejuran’s PN treatment is particularly effective for these issues.
Once again, please note that all three of these treatments are medical procedures. It is essential to choose a qualified dermatology or cosmetic clinic and have them performed by an experienced doctor after a thorough pre-treatment assessment to ensure safe and optimal results.
The information in this article is for reference only and cannot replace the advice of a professional doctor. If you have any medical concerns, please consult a qualified dermatologist or cosmetic surgeon directly.
